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      Anti-HPK1 antibody[STJ93590]
      • Anti-HPK1 antibody[STJ93590]
      • Anti-HPK1 antibody[STJ93590]

      Anti-HPK1 antibody[STJ93590]

      Product nameAnti-HPK1 antibodyShort DescriptionRabbit polyclonal against HPK1DescriptionHPK1 is a protein encoded by the MAP4

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      Product nameAnti-HPK1 antibody
      Short DescriptionRabbit polyclonal against HPK1
      DescriptionHPK1 is a protein encoded by the MAP4K1 gene which is approximately 91, 3 kDa. HPK1 is localised to the cytoplasm and cell membrane. It is involved in the TGF-beta pathway, MAPK signalling pathway, B cell receptor signalling pathway and NF-kappa B signalling. It is a serine/threonine-protein kinase, which may play a role in the response to environmental stress. It appears to act upstream of the JUN N-terminal pathway and may also play a role in hematopoietic lineage decisions and growth regulation. HPK1 is expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Mutations in the MAP4K1 gene may result in Paget disease. STJ93590 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of HPK1 protein.
      ApplicationsELISA, IHC-p, WB
      Dilution rangeWB 1:500-1:2000
      ELISA 1:10000
      SpecificityHPK1 polyclonal antibody detects endogenous levels of HPK1 protein.
      Protein NameMitogen-Activated Protein Kinase Kinase Kinase Kinase 1
      Hematopoietic Progenitor Kinase
      Mapk/Erk Kinase Kinase Kinase 1
      Mek Kinase Kinase 1
      Mekkk 1
      ImmunogenSynthesized peptide derived from human HPK1
      Immunogen Region340-420 aa, Internal
      Storage InstructionStore at-20°C, and avoid repeat freeze-thaw cycles.
      NoteFOR RESEARCH USE ONLY (RUO).


      HostRabbit
      ClonalityPolyclonal
      ReactivityHuman, Mouse
      ConjugationUnconjugated
      Concentration1 mg/ml
      PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      IsotypeIgG
      FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      Gene ID11184
      Gene SymbolMAP4K1
      Molecular Weight91 kDa
      Database LinksHGNC:6863
      OMIM:601983
      Alternative NamesAnti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 antibody
      Anti-Hematopoietic Progenitor Kinase antibody
      Anti-Mapk/Erk Kinase Kinase Kinase 1 antibody
      Anti-Mek Kinase Kinase 1 antibody
      Anti-Mekkk 1 antibody
      Anti-MAP4K1 HPK1 antibody
      FunctionSerine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate. Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production.
      Post-translational ModificationsAutophosphorylates: phosphorylation promotes ubiquitination by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex, leading to its degradation by the proteasome.; Tyrosine-phosphorylated after activation of hemopoietic cells.; Ubiquitinated by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex following autophosphorylation, leading to its degradation by the proteasome.
      Tissue SpecificityExpressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine.
      Swiss-Prot KeyM4K1_HUMAN


      Anti-HPK1 antibody[STJ93590](圖1)

       
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