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      Anti-PD-L1 antibody[STJ130023]
      • Anti-PD-L1 antibody[STJ130023]
      • Anti-PD-L1 antibody[STJ130023]
      • Anti-PD-L1 antibody[STJ130023]

      Anti-PD-L1 antibody[STJ130023]

      Product nameAnti-PD-L1 antibodyShort DescriptionRabbit monoclonal against PD-L1DescriptionProgrammed death-ligand 1 (PD-L1) i

      • 宿主:Rabbit
      • 克隆性:Monoclonal
      • 應用:WB
      • 規格:50ul,100ul
      • 聯系:錢女士 15301726783
      Product nameAnti-PD-L1 antibody[STJ130023]
      Short DescriptionRabbit monoclonal against PD-L1
      DescriptionProgrammed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and nonhematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PDL1 has become an important biomarker and immunotherapy target for many types of malignancies.
      Specificityhuman PD-L1
      Protein NameProgrammed death-ligand 1
      ImmunogenRecombinant human PD-L1 extracellular domain
      Storage InstructionStore Anti-PD-L1 Antibody at -20°C, and avoid repeated freeze-thaw cycles.
      NoteFor Research Use Only (RUO)
      Validated ApplicationELISA WB FC
      Clone ID8C6
      PurificationProtein A agarose affinity chromatography of tissue culture supernatant
      FormulationPBS with 0.09% sodium azide, and 50% glycerol at pH7.4
      Gene ID29126
      Gene SymbolCD274
      Molecular Weight34 kDa
      Database LinksHGNC:17635
      Alternative NamesProgrammed death-ligand 1
      FunctionInvolved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443}.
      Cellular LocalizationIsoform 1: Cell membrane {ECO:0000269|PubMed:15780196}. Single-pass type I membrane protein {ECO:0000255}.. Isoform 2: Endomembrane system {ECO:0000269|PubMed:15780196}. Single-pass type I membrane protein {ECO:0000255}.
      Tissue SpecificityHighly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443}.
      Swiss-Prot KeyQ9NZQ7_HUMAN

      Anti-PD-L1 antibody[STJ130023](圖4)