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      Anti-Bax antibody[STJ97729]
      • Anti-Bax antibody[STJ97729]
      • Anti-Bax antibody[STJ97729]

      Anti-Bax antibody[STJ97729]

      Product nameAnti-Bax antibodyShort DescriptionMouse monoclonal against BaxDescriptionMouse monoclonal to Bax.ApplicationsIHC-

      • 宿主:Mouse
      • 克隆性:Monoclonal
      • 種屬:Human, Mouse, Rat
      • 應用:IHC-p, WB
      • 規格:20ul,50ul,100ul,200ul
      • 聯系:錢女士 15301726783
      Product nameAnti-Bax antibodySTJ97729]
      Short DescriptionMouse monoclonal against Bax
      DescriptionMouse monoclonal to Bax.
      ApplicationsIHC-p, WB
      Dilution rangeWB 1:1000-2000
      IHC 1:100-200
      SpecificityBax protein detects endogenous levels of BAX
      Protein NameApoptosis Regulator Bax
      Bcl-2-Like Protein 4
      Immunogensynthetic peptide derived from Bax
      Immunogen Region30-110 aa
      Storage InstructionStore at-20°C, and avoid repeat freeze-thaw cycles.
      Clone ID1C1
      ReactivityHuman, Mouse, Rat
      Concentration1 mg/ml
      PurificationThe antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      Gene ID581
      Gene SymbolBAX
      Database LinksHGNC:959
      Alternative NamesAnti-Apoptosis Regulator Bax antibody
      Anti-Bcl-2-Like Protein 4 antibody
      Anti-Bcl2-L-4 antibody
      Anti-BAX BCL2L4 antibody
      FunctionPlays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
      Cellular LocalizationIsoform Alpha: Mitochondrion Outer Membrane
      Single-Pass Membrane Protein
      Colocalizes With 14-3-3 Proteins In The Cytoplasm
      Under Stress Conditions
      Undergoes A Conformation Change That Causes Release From Jnk-Phosphorylated 14-3-3 Proteins And Translocation To The Mitochondrion Membrane
      Isoform Beta: Cytoplasm
      Isoform Gamma: Cytoplasm
      Isoform Delta: Cytoplasm
      Tissue SpecificityExpressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate c
      Swiss-Prot KeyBAX_HUMAN

      Anti-Bax antibody[STJ97729](圖1)