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      Anti-Bcl-2 antibody[STJ96943]
      • Anti-Bcl-2 antibody[STJ96943]
      • Anti-Bcl-2 antibody[STJ96943]

      Anti-Bcl-2 antibody[STJ96943]

      Product nameAnti-Bcl-2 antibodyShort DescriptionMouse monoclonal against Bcl-2DescriptionBcl-2 is a protein encoded by the BC

      • 宿主:Mouse
      • 克隆性:Monoclonal
      • 種屬:Chicken, Human, Mouse, Rat
      • 應用:IF, IHC-p, WB
      • 規格:20ul,50ul,100ul,200ul
      • 聯系:錢女士 15301726783
      標簽:
      Product nameAnti-Bcl-2 antibody
      Short DescriptionMouse monoclonal against Bcl-2
      DescriptionBcl-2 is a protein encoded by the BCL2 gene which is approximately 26, 2 kDa. Bcl-2 is localised to the mitochondrion outer membrane, endoplasmic reticulum membrane and nucleus membrane. It is involved in PEDF induced signalling, the TGF-Beta pathway and TNFR1 pathway. It suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability and appears to function in a feedback loop system with caspases. It inhibits caspase activity either by preventing the release of cytochrome C from the mitochondria and/or by binding to the apoptosis-activating factor. Bcl-2 is expressed in a variety of human tissues. Mutations in the BCL2 gene may result in follicular lymphoma. STJ96943 was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This antibody detects endogenous Bcl-2 proteins.
      ApplicationsIF, IHC-p, WB
      Dilution rangeIF 1:50-200
      WB 1:1000~2000
      IHC 1:200
      SpecificityThe antibody detects endogenous Bcl-2 proteins.
      Protein NameApoptosis Regulator Bcl-2
      ImmunogenSynthetic Peptide
      Storage InstructionStore at-20°C, and avoid repeat freeze-thaw cycles.
      NoteFOR RESEARCH USE ONLY (RUO).


      HostMouse
      ClonalityMonoclonal
      Clone ID6B5
      ReactivityChicken, Human, Mouse, Rat
      ConjugationUnconjugated
      PurificationThe antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      IsotypeIgG1
      FormulationPBS, pH 7.4, containing 0.5% BSA, 0.02% sodium azide and 50% Glycerol.
      Gene ID596
      Gene SymbolBCL2
      Database LinksHGNC:990
      OMIM:151430
      Alternative NamesAnti-Apoptosis Regulator Bcl-2 antibody
      Anti-BCL2 antibody
      FunctionSuppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.
      Post-translational ModificationsPhosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates starvation-induced autophagy. Dephosphorylated by protein phosphatase 2A (PP2A).; Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity, causes the release of cytochrome c into the cytosol promoting further caspase activity.; Monoubiquitinated by PRKN, leading to increase its stability. Ubiquitinated by SCF(FBXO10), leading to its degradation by the proteasome.
      Cellular LocalizationMitochondrion Outer Membrane
      Single-Pass Membrane Protein
      Nucleus Membrane
      Endoplasmic Reticulum Membrane
      Tissue SpecificityExpressed in a variety of tissues.
      Swiss-Prot KeyBCL2_HUMAN

      Anti-Bcl-2 antibody[STJ96943](圖1)

       
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